Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33159176" target="_blank" >RIV/61989592:15110/16:33159176 - isvavai.cz</a>
Result on the web
<a href="http://journal.frontiersin.org/article/10.3389/fimmu.2016.00274/full" target="_blank" >http://journal.frontiersin.org/article/10.3389/fimmu.2016.00274/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2016.00274" target="_blank" >10.3389/fimmu.2016.00274</a>
Alternative languages
Result language
angličtina
Original language name
Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations
Original language description
Idiopathic pulmonary fibrosis (IPF) affects lung parenchyma with progressing fibrosis. In this study, we aimed to replicate MUC5B rs35705950 variants and determine new plausible candidate variants for IPF among four different European populations. We genotyped 26 IPF candidate loci in 165 IPF patients from four European countries, such as Czech Republic (n = 41), Germany (n = 33), Greece (n = 40), France (n = 51), and performed association study comparing observed variant distribution with that obtained in a genetically similar Czech healthy control population (n = 96) described in our earlier data report. A highly significant association for a promoter variant (rs35705950) of mucin encoding MUC5B gene was observed in all IPF populations, individually and combined [odds ratio (95% confidence interval); p-value as 5.23 (8.94-3.06); 1.80 x 10(-11)]. Another non-coding variant, rs7934606 in MUC2 was significant among German patients [2.85 (5.05-1.60); 4.03 x 10(-4)] and combined European IPF cases [2.18 (3.16-1.50); 3.73 x 10(-5)]. The network analysis for these variants indicated gene-gene and gene-phenotype interactions in IPF and lung biology. With replication of MUC5B rs35705950 previously reported in U.S. populations of European descent and indicating other plausible polymorphic variants relevant for IPF, we provide additional reference information for future extended functional and population studies aimed, ideally with inclusion of clinical parameters, at identification of IPF genetic markers.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
274
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
"274-1"-"274-8"
UT code for WoS article
000379401800002
EID of the result in the Scopus database
2-s2.0-84983335825