MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73623349" target="_blank" >RIV/61989592:15110/23:73623349 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/23:10158267

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/resp.14440" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/resp.14440</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/resp.14440" target="_blank" >10.1111/resp.14440</a>

Result language

angličtina

Original language name

MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis

Original language description

Background and Objective: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association between MUC5B rs35705950, survival and patient characteristics in a real-world population of European IPF patients. Methods: In this retrospective study, 1751 patients with IPF from 8 European centres were included. MUC5B rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed. Results: In a multi-variate Cox proportional hazard model the MUC5B minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. MUC5B minor allele carriers were significantly older at diagnosis (p = 0.001). The percentage of MUC5B minor allele carriers increased significantly with age from 44% in patients aged &lt;56 year, to 63% in patients aged &gt;75. In IPF patients aged &lt;56, the MUC5B minor allele was not associated with survival. In IPF patients aged &gt;= 56, survival was significantly better for MUC5B minor allele carriers (45 months [CI: 42-49]) compared to non-carriers (29 months [CI: 26-33]; p = 4 x 10(-12)). Conclusion: MUC5B minor allele carriage associates with a better median transplant-free survival of 16 months in the European IPF population aged over 56 years. MUC5B genotype status might aid disease prognostication in clinical management of IPF patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RESPIROLOGY

ISSN

1323-7799

e-ISSN

1440-1843

Volume of the periodical

28

Issue of the periodical within the volume

5

Country of publishing house

AU - AUSTRALIA

Number of pages

10

Pages from-to

455-464

UT code for WoS article

000903699500001

EID of the result in the Scopus database

2-s2.0-85149541135