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Characterization of three CYP2C19 gene variants by Mass Array and Point of care

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160600" target="_blank" >RIV/61989592:15110/16:33160600 - isvavai.cz</a>

  • Result on the web

    <a href="https://link.springer.com/article/10.1007%2Fs00005-016-0440-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs00005-016-0440-8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00005-016-0440-8" target="_blank" >10.1007/s00005-016-0440-8</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Characterization of three CYP2C19 gene variants by Mass Array and Point of care

  • Original language description

    Distribution of cytochrome P450 2C19 enzyme gene (CYP2C19) variants affecting metabolism of clopidogrel was determined in 526 Czech patients after percutaneous coronary intervention using MassARRAY genotyping and compared to distribution in other populations of European descent. Fifty three (10%) patients underwent parallel determination of CYP2C19 genotypes from buccal swabs by a point of care (POC) technique with 100% concordance to the main genotyping platform. Observed CYP2C19 genotypes were related to clopidogrel metabolism phenotypes and discussed in population context. Hereby presented methodologies provide accurate CYP2C19 genotyping results in a relatively short time of one up to 12 hours and may, therefore, find the relevant place in the field of genotype-guided antiplatelet therapy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Archivum Immunologiae et Therapiae Experimentalis

  • ISSN

    0004-069X

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    Suppl 1

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    99-107

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85009291472