Characterization of three CYP2C19 gene variants by Mass Array and Point of care
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160600" target="_blank" >RIV/61989592:15110/16:33160600 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00005-016-0440-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs00005-016-0440-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00005-016-0440-8" target="_blank" >10.1007/s00005-016-0440-8</a>
Alternative languages
Result language
angličtina
Original language name
Characterization of three CYP2C19 gene variants by Mass Array and Point of care
Original language description
Distribution of cytochrome P450 2C19 enzyme gene (CYP2C19) variants affecting metabolism of clopidogrel was determined in 526 Czech patients after percutaneous coronary intervention using MassARRAY genotyping and compared to distribution in other populations of European descent. Fifty three (10%) patients underwent parallel determination of CYP2C19 genotypes from buccal swabs by a point of care (POC) technique with 100% concordance to the main genotyping platform. Observed CYP2C19 genotypes were related to clopidogrel metabolism phenotypes and discussed in population context. Hereby presented methodologies provide accurate CYP2C19 genotyping results in a relatively short time of one up to 12 hours and may, therefore, find the relevant place in the field of genotype-guided antiplatelet therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archivum Immunologiae et Therapiae Experimentalis
ISSN
0004-069X
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
Suppl 1
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
99-107
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85009291472