Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73577778" target="_blank" >RIV/61989592:15110/17:73577778 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10363462 RIV/00098892:_____/17:N0000039
Result on the web
<a href="https://obd.upol.cz/id_publ/333154559" target="_blank" >https://obd.upol.cz/id_publ/333154559</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00498254.2016.1195028" target="_blank" >10.1080/00498254.2016.1195028</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities
Original language description
The possibility of interaction of isoflavonoids with concomitantly taken drugs to determined isoflavonoids safety was studied. Inhibition of nine forms of cytochrome P450 (CYP3A4, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2C9, CYP2D6 and CYP2E1) by 12 isoflavonoids (daidzein, genistein, biochanin A, formononetin, glycitein, equol and six glucosides, daidzin, puerarin, genistin, sissotrin, ononin and glycitin) was studied systematically. The most potent inhibitors were genistein and daidzein inhibiting noncompetitively the CYP2C9 with Ki of 35.95 ± 6.96 and 60.56 ± 3.53 umol/l and CYP3A4 (inhibited by genistein with Ki of 23.25 ± 5.85 umol/l also by a noncompetitive mechanism). Potent inhibition of CYP3A4 was observed also with biochanin A (Ki of 57.69 ± 2.36 umol/l) and equol (Ki of 38.47 ± 2.32 umol/l). Genistein and daidzein inhibit noncompetitively CYP3A4 and CYP2C9. With plasma levels in micromolar range, a clinically important interaction with concomitantly taken drugs does not seem to be probable.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Xenobiotica
ISSN
0049-8254
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
324-331
UT code for WoS article
000395347600007
EID of the result in the Scopus database
2-s2.0-84975109070