Longitudinal changes of cortical microstructure in Parkinson's disease assessed with T1 relaxometry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73580298" target="_blank" >RIV/61989592:15110/17:73580298 - isvavai.cz</a>

Result on the web

<a href="https://obd.upol.cz/id_publ/333160049" target="_blank" >https://obd.upol.cz/id_publ/333160049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nicl.2016.12.025" target="_blank" >10.1016/j.nicl.2016.12.025</a>

Result language

angličtina

Original language name

Longitudinal changes of cortical microstructure in Parkinson's disease assessed with T1 relaxometry

Original language description

BACKGROUND: Histological evidence suggests that pathology in Parkinson&apos;s disease (PD) goes beyond nigrostriatal degeneration and also affects the cerebral cortex. Quantitative MRI (qMRI) techniques allow the assessment of changes in brain tissue composition. However, the development and pattern of disease-related cortical changes have not yet been demonstrated in PD with qMRI methods. The aim of this study was to investigate longitudinal cortical microstructural changes in PD with quantitative T1 relaxometry. METHODS: 13 patients with mild to moderate PD and 20 matched healthy subjects underwent high resolution T1 mapping at two time points with an interval of 6.4 years (healthy subjects: 6.5 years). Data from two healthy subjects had to be excluded due to MRI artifacts. Surface-based analysis of cortical T1 values was performed with the FreeSurfer toolbox. RESULTS: In PD patients, a widespread decrease of cortical T1 was detected during follow-up which affected large parts of the temporo-parietal and occipital cortices and also frontal areas. In contrast, age-related T1 decrease in the healthy control group was much less pronounced and only found in lateral frontal, parietal and temporal areas. Average cortical T1 values did not differ between the groups at baseline (p = 0.17), but were reduced in patients at follow-up (p = 0.0004). Annualized relative changes of cortical T1 were higher in patients vs. healthy subjects (patients: - 0.72 ± 0.64%/year; healthy subjects: - 0.17 ± 0.41%/year, p = 0.007).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroimage

ISSN

1053-8119

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

405-414

UT code for WoS article

000401413700047

EID of the result in the Scopus database

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