Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582964" target="_blank" >RIV/61989592:15110/17:73582964 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00330-016-4485-1" target="_blank" >http://dx.doi.org/10.1007/s00330-016-4485-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00330-016-4485-1" target="_blank" >10.1007/s00330-016-4485-1</a>

Result language

angličtina

Original language name

Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years.

Original language description

Objectives T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. Methods T1 mapping was performed in 17 healthy subjects (range 51–77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. Results The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. Conclusions T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30230 - Other clinical medicine subjects

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Radiology

ISSN

0938-7994

e-ISSN

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Volume of the periodical

2017

Issue of the periodical within the volume

27

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1568-1576

UT code for WoS article

000396040600027

EID of the result in the Scopus database

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