The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73582196" target="_blank" >RIV/61989592:15110/17:73582196 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/17:N0000093
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/php.12755/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/php.12755/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/php.12755" target="_blank" >10.1111/php.12755</a>
Alternative languages
Result language
angličtina
Original language name
The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin.
Original language description
Quercetin, one of the most abundant polyphenols in the plant kingdom has been shown to be photodegraded on exposure to UV light. Despite the fact, it is a component of several dermatological preparations. Its phototoxic potential has not been evaluated to date. The aim of this study was to assess whether photo-induced degradation of quercetin is linked to phototoxic effects on living cells. Its dihydro derivative, taxifolin, was included in the study. For evaluation, the 3T3 Neutral Red Uptake Phototoxicity Test according to OECD TG 432 was used. To better approximate human skin, HaCaT keratinocytes, normal human epidermal keratinocytes and dermal fibroblasts were used, apart from the Balb/c 3T3 cell line. Quercetin showed a dose-dependent photodegradation in aqueous and organic environments and a phototoxic effect on all used cells. Quercetin pretreatment and following UVA exposure resulted in increased reactive oxygen species production and intracellular glutathione level depletion in human dermal fibroblasts. Taxifolin was found completely nonphototoxic and photostable. As only in vitro methodology was used, further studies using 3D skin models and/or human volunteers are needed to confirm whether exposure to sunlight, tanning sunbeds and/or phototherapy in people using cosmetics containing quercetin is a health risk.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA15-10897S" target="_blank" >GA15-10897S: Modulation of human skin cell responses to UVA radiation by silymarin components</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Photochemistry and Photobiology
ISSN
0031-8655
e-ISSN
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Volume of the periodical
93
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1240-1247
UT code for WoS article
000411003000012
EID of the result in the Scopus database
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