Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73583550" target="_blank" >RIV/61989592:15110/17:73583550 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/17:N0000034

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2017.015" target="_blank" >http://dx.doi.org/10.5507/bp.2017.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2017.015" target="_blank" >10.5507/bp.2017.015</a>

Result language

angličtina

Original language name

Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage

Original language description

Aims. To evaluate the serum levels of matrix metalloproteinase-3 (MMP-3) as a potential marker of disease aktivity and joint damage in 92 patients with rheumatoid arthritis (RA), compared to 24 osteoarthritis (OA) patients and 26 healthy controls. Methods. The concentrations of MMP-3 were measured by ELISA using the commercial kit AESKULISA DF MMP-3 (AESKU.Diagnostics, Germany) and compared with other laboratory parameters routinely used to assess the dinase status, clinical score (DAS28) and radiographic stage in the group of RA patients. Results. The mean serum concentrations of MMP-3 were 199.1 ± 160 ng/mL in RA patients, 113.9 ± 96.9 ng/mL in OA patients and 48.3 ± 19.2 in healthy controls. The differences were highly significant: RA patients and healthy controls (P&lt;0.0001), RA and OA patients (P=0.008) as well as between OA patients and controls (P=0.009). MMP-3 concentrations were further compared with other laboratory parameters and clinical and structural damage data. There were correlations between MMP-3 and CRP (r=0.304, P&lt;0.01), DAS28 (r=0.301, P&lt;0.05), levels of anti-cyclic citrullinated peptide antibodies (r=0.241, P&lt;0.05), erythrocyte sedimentation rate (r=0.200, P=0.059) and radiographic disease stage (r=0.197, P=0.063). Conclusion. These results demonstrated that measurement of MMP-3 could become a marker of disease activity in RA patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV15-28659A" target="_blank" >NV15-28659A: Prognostic factors of organ and tissue damage in selected systemic autoimunne diseases</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

161

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

296-302

UT code for WoS article

000418004800009

EID of the result in the Scopus database

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