Bacterial resistance to silver nanoparticles and how to overcome it

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73587069" target="_blank" >RIV/61989592:15110/18:73587069 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/18:73587069

Result on the web

<a href="http://www.nature.com/articles/s41565-017-0013-y" target="_blank" >http://www.nature.com/articles/s41565-017-0013-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41565-017-0013-y" target="_blank" >10.1038/s41565-017-0013-y</a>

Result language

angličtina

Original language name

Bacterial resistance to silver nanoparticles and how to overcome it

Original language description

Silver nanoparticles have already been successfully applied in various biomedical and antimicrobial technologies and products used in everyday life. Although bacterial resistance to antibiotics has been extensively discussed in the literature, the possible development of resistance to silver nanoparticles has not been fully explored. We report that the Gram-negative bacteria Escherichia coli 013, Pseudomonas aeruginosa CCM 3955 and E. coli CCM 3954 can develop resistance to silver nanoparticles after repeated exposure. The resistance stems from the production of the adhesive flagellum protein flagellin, which triggers the aggregation of the nanoparticles. This resistance evolves without any genetic changes; only phenotypic change is needed to reduce the nanoparticles&apos; colloidal stability and thus eliminate their antibacterial activity. The resistance mechanism cannot be overcome by additional stabilization of silver nanoparticles using surfactants or polymers. It is, however, strongly suppressed by inhibiting flagellin production with pomegranate rind extract.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Nanotechnology

ISSN

1748-3387

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

65-71

UT code for WoS article

000419783900021

EID of the result in the Scopus database

2-s2.0-85036530507