Multifarious Diagnostic Possibilities of the S100 Protein Family: Predominantly in Pediatrics and Neonatology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590215" target="_blank" >RIV/61989592:15110/18:73590215 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12519-018-0163-5" target="_blank" >http://dx.doi.org/10.1007/s12519-018-0163-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12519-018-0163-5" target="_blank" >10.1007/s12519-018-0163-5</a>

Result language

angličtina

Original language name

Multifarious Diagnostic Possibilities of the S100 Protein Family: Predominantly in Pediatrics and Neonatology

Original language description

Background: Numerous articles related to S100 proteins have been recently published. This review aims to introduce this large protein family and its importance in the diagnostics of many pathological conditions in children and adults. Data sources: Based on original publications found in database systems, we summarize the current knowledge about the S100 protein group and highlight the most important proteins with focus on pediatric use. Results: The S100 family is composed of Ca2+ and Zn2+ binding proteins, which are present only in vertebrates. Some of these proteins can be used as diagnostic markers in cardiology (S100A1, S100A12), oncology (S100A2, S100A5, S100A6, S100A14, S100A16, S100P, S100B), neurology (S100B), rheumatology (S100A8/A9, S100A4, S100A6, and S100A12), nephrology and infections (S100A8, S100A9, S100A8/A9, S100A12). The most useful S100 proteins in pediatrics are S100A8, S100A9, heterodimers S100A8/A9, S100B and S100A12. Conclusions: The S100 family members are promising biomarkers and provide numerous possibilities for implementation into clinical practice to optimize the differential diagnostic process.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Pediatrics

ISSN

1708-8569

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

4

Country of publishing house

CN - CHINA

Number of pages

7

Pages from-to

315-321

UT code for WoS article

000444479500002

EID of the result in the Scopus database

2-s2.0-85047909606