Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000007" target="_blank" >RIV/00023728:_____/19:N0000007 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00109000 RIV/00216208:11110/19:10396060
Result on the web
<a href="https://doi.org/10.1007/s00296-018-4190-2" target="_blank" >https://doi.org/10.1007/s00296-018-4190-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-018-4190-2" target="_blank" >10.1007/s00296-018-4190-2</a>
Alternative languages
Result language
angličtina
Original language name
Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study
Original language description
S100 proteins are currently being investigated as potential diagnostic and prognostic biomarkers of several cancers and inflammatory diseases. The aims of this study were to analyse the plasma levels of S100A4, S100A8/9 and S100A12 in patients with incomplete systemic lupus erythematosus (iSLE), in patients with established SLE and in healthy controls (HCs) and to investigate the potential utility of the S100 proteins as diagnostic or activity-specific biomarkers in SLE. Plasma levels were measured by ELISA in a cross-sectional cohort study of 44 patients with SLE, 8 patients with iSLE and 43 HCs. Disease activity was assessed using the SLEDAI-2K. The mean levels of all S100 proteins were significantly higher in SLE patients compared to HCs. In iSLE patients, the levels of S100A4 and S100A12 but not S100A8/9 were also significantly higher compared to HCs. There were no significant differences in S100 levels between the iSLE and SLE patients. Plasma S100 proteins levels effectively discriminated between SLE patients and HCs. The area under the curve (AUC) for S100A4, S100A8/9 and S100A12 plasma levels was 0.989 (95% CI 0.976-1.000), 0.678 (95% CI 0.563-0.792) and 0.807 (95% CI 0.715-0.899), respectively. S100 levels did not differentiate between patients with high and low disease activity. Only the S100A12 levels were significantly associated with SLEDAI-2K and with cSLEDAI-2K. S100 proteins were significantly higher in SLE patients compared HCs and particularly S100A4 could be proposed as a potential diagnostic biomarker for SLE.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RHEUMATOLOGY INTERNATIONAL
ISSN
0172-8172
e-ISSN
1437-160X
Volume of the periodical
39
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
469-478
UT code for WoS article
000458566100007
EID of the result in the Scopus database
2-s2.0-85056002110