Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73593985" target="_blank" >RIV/61989592:15110/19:73593985 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11307-019-01325-6" target="_blank" >https://link.springer.com/article/10.1007/s11307-019-01325-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11307-019-01325-6" target="_blank" >10.1007/s11307-019-01325-6</a>

Result language
angličtina
Original language name
Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection
Original language description
Due to the lack of sensitivity and specificity of current diagnostic methods, invasive fungal diseases are a major cause of high mortality rates (up to 50 % [1, 2]) and elevated healthcare costs in Europe [3]. Aspergillus fumigatus is the major cause for pulmonary fungal infections in immunocompromised patients including also transplant recipients and patients undergoing aggressive anti-cancer chemotherapy [4]. Early diagnosis of invasive pulmonary aspergillosis (IPA) is a key to improve survival rate. Various clinical tests and techniques as well as X-ray computed tomography (CT) have shown unsuccessful diagnosis in terms of specificity and sensitivity. Scintigraphic techniques such as single photon emission computer tomography (SPECT) and positron emission tomography (PET) have been applied for imaging fungal infections using non-specific radiotracers including [99mTc]leucocytes, [99mTc]peptides, [99mTc]anti-granulocyte antibody, [67Ga]citrate (inflammation radiotracer), and even 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) [5]. These tracers have revealed only suboptimal characteristics for fungal detection.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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