Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F23%3A73622092" target="_blank" >RIV/61989592:15640/23:73622092 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/23:73622092
Result on the web
<a href="https://academic.oup.com/jid/article/228/Supplement_4/S259/7288373?login=true" target="_blank" >https://academic.oup.com/jid/article/228/Supplement_4/S259/7288373?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/infdis/jiad067" target="_blank" >10.1093/infdis/jiad067</a>

Result language
angličtina
Original language name
Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future
Original language description
Invasive fungal infections have become a major challenge for public health, mainly due to the growing numbers of immunocompromised patients, with high morbidity and mortality. Currently, conventional imaging modalities such as computed tomography and magnetic resonance imaging contribute largely to the noninvasive diagnosis and treatment evaluation of those infections. These techniques, however, often fall short when a fast, noninvasive and specific diagnosis of fungal infection is necessary. Molecular imaging, especially using nuclear medicine-based techniques, aims to develop fungal-specific radiotracers that can be tested in preclinical models and eventually translated to human applications. In the last few decades, multiple radioligands have been developed and tested as potential fungal-specific tracers. These include radiolabeled peptides, antifungal drugs, siderophores, fungal-specific antibodies, and sugars. In this review, we provide an overview of the pros and cons of the available radiotracers. We also address the future prospects of fungal-specific imaging.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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