Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73594468" target="_blank" >RIV/61989592:15110/19:73594468 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520011/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520011/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/aging.101922" target="_blank" >10.18632/aging.101922</a>
Alternative languages
Result language
angličtina
Original language name
Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Original language description
The biosynthesis of ribosomes is a complex process that requires the coordinated action of many factors and a huge energy investment from the cell. Ribosomes are essential for protein production, and thus for cellular survival, growth and proliferation. Ribosome biogenesis is initiated in the nucleolus and includes: the synthesis and processing of ribosomal RNAs, assembly of ribosomal proteins, transport to the cytoplasm and association of ribosomal subunits. The disruption of ribosome biogenesis at various steps, with either increased or decreased expression of different ribosomal components, can promote cell cycle arrest, senescence or apoptosis. Additionally, interference with ribosomal biogenesis is often associated with cancer, aging and age-related degenerative diseases. Here, we review current knowledge on impaired ribosome biogenesis, discuss the main factors involved in stress responses under such circumstances and focus on examples with clinical relevance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aging-US
ISSN
1945-4589
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
29
Pages from-to
2512-2540
UT code for WoS article
000466768900026
EID of the result in the Scopus database
2-s2.0-85065597922