Effect of AgNPs on the human reconstructed epidermis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73596103" target="_blank" >RIV/61989592:15110/19:73596103 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853009/pdf/ITX-11-289.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853009/pdf/ITX-11-289.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/intox-2018-0028" target="_blank" >10.2478/intox-2018-0028</a>
Alternative languages
Result language
angličtina
Original language name
Effect of AgNPs on the human reconstructed epidermis
Original language description
Nanoparticles are utilized in a wide range of industries. The most studied silver nanoparticles (AgNPs) are used in medicine and also in several wound dressings due to their antimicrobial properties. The inflammatory response or potential morphological changes of skin cells after their application are not well known yet. In our study we used the model of human reconstructed epidermis (RHE), prepared in our laboratory, to evaluate whether the AgNPs penetrate through RHE, induce some morphological changes of keratinocytes or influence the production of pro-inflammatory cytokines (IL-6 and IL-8). After the application of three different concentrations (25 ppm, 2.5 ppm, 0.25 ppm) of AgNPs to of RHE for 24 hours we verified that AgNPs did not affect the production of pro-inflammatory cytokines (IL-6 and IL-8) and neither did they influence the expression of keratin K14 and loricrin. The morphology of the cells was likewise unchanged. Based on these results we conclude that AgNPs do not have any negative effect on the morphological changes and do not increase the production of pro-inflammatory cytokines.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Interdisciplinary Toxicology
ISSN
1337-6853
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
"289–293"
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85074592839