Intravenous Thrombolysis in Posterior Circulation Stroke.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73596408" target="_blank" >RIV/61989592:15110/19:73596408 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fneur.2019.00417/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fneur.2019.00417/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fneur.2019.00417" target="_blank" >10.3389/fneur.2019.00417</a>

Result language

angličtina

Original language name

Intravenous Thrombolysis in Posterior Circulation Stroke.

Original language description

ackground: Intravenous thrombolysis (IVT) is a standard treatment for both anterior circulation ischemic stroke (ACIS) and posterior circulation ischemic stroke (PCIS). PCIS is a clinical syndrome associated with ischemia-related changes in the territory of the posterior circulation arteries. Embolism is the most common stroke mechanism in posterior circulation. PCIS represents 12–19% of all IVT-treated strokes. Methods and Results: We searched the PubMed database for assessments of intracerebral hemorrhage (ICH) and clinical outcome in PCIS patients treated with IVT. ICH occurs in 0–6.9% of posterior ischemic stroke depending on the definition of symptomatic ICH, and any ICH in 17–23.4% of posterior ischemic stroke. For patients with PCIS, 38–49% have a favorable outcome (mRS 0–1) after IVT. Better clinical outcomes occur more often in patients with PCIS than in those with ACIS. The mortality rate among PCIS patients treated with IVT ranges from 9 to 19%; it does not differ significantly between PCIS and ACIS. Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset. FUNDING This study was conducted on an academic basis and was supported by the AZV CR – Health Research Council of the Czech Republic No. 17-29452A, and 17-30101A; by the institutional support of the Ministry of Health of the Czech Republic MH CZ – DRO (FNOL, 00098892) – 2016, 2017, 2018 and by a grant from the Internal Grant Agency of Palacky University IGA_LF_2018_017 and IGA_LF_2019_010.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neurology

ISSN

1664-2295

e-ISSN

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Volume of the periodical

2019

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

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UT code for WoS article

000466183600001

EID of the result in the Scopus database

2-s2.0-85067844628