Brain Imaging Findings and Response to Intravenous Thrombolysis in Posterior Circulation Stroke

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73603124" target="_blank" >RIV/61989592:15110/21:73603124 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/21:N0000080

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs12325-020-01547-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs12325-020-01547-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12325-020-01547-z" target="_blank" >10.1007/s12325-020-01547-z</a>

Result language

angličtina

Original language name

Brain Imaging Findings and Response to Intravenous Thrombolysis in Posterior Circulation Stroke

Original language description

Introduction: Intravenous thrombolysis (IVT) is a standard treatment for both anterior circulation ischaemic stroke (ACIS) and posterior circulation ischaemic stroke (PCIS). Our aim was to evaluate the predictors for a good clinical outcome and intracerebral haemorrhage (ICH) in patients undergoing posterior circulation IVT based on the initially performed CT or MR imaging. Methods: The study cohort consisted of 1643 consecutive patients with acute ischaemic stroke (1440 ACIS, 203 PCIS cases) who underwent IVT. ICH was classified according to the European Cooperative Acute Stroke Study (ECASS) I protocol. Clinical outcome was assessed using the modified Rankin scale (mRS). Early ischaemic signs and pre-existing structural signs were assessed. Results: Good clinical outcomes (mRS 0-1) were noted in 45.3% of patients with PCIS, with a mortality rate of 14.8%. ICH was noted in 8.3%, and a large haemorrhage was found in 2.4% of patients. Some early ischaemic signs and pre-existing structural signs on initial CT/MR imaging correlated significantly with the 90-day clinical outcome. Conclusions: Early ischaemic signs and pre-existing structural signs should be considered during the assessment of patients with PCIS eligible for IVT. Tissue hypoattenuation on initial CT scans correlates with an increased risk of death. Similarly to anterior circulation, atrophy on initial MRI may negatively predict good clinical outcome in posterior circulation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ADVANCES IN THERAPY

ISSN

0741-238X

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

627-639

UT code for WoS article

000590050400001

EID of the result in the Scopus database

2-s2.0-85096070238