Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597032" target="_blank" >RIV/61989592:15110/19:73597032 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/19:73597032
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0223523419306993?token=B9C3612B47A2D55311625A16D10B89D3596D346B6C3902ECBC9A3D908AC84A3ED08D4775520A4BC87E1D34F82B5B049C" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0223523419306993?token=B9C3612B47A2D55311625A16D10B89D3596D346B6C3902ECBC9A3D908AC84A3ED08D4775520A4BC87E1D34F82B5B049C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2019.111569" target="_blank" >10.1016/j.ejmech.2019.111569</a>

Result language
angličtina
Original language name
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases
Original language description
This article provides an overview of compounds based on imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine scaffolds, which act as potent ligands of diverse molecular targets localized in the central nervous system. A literature survey revealed that various imidazopyridines can be powerful modulators of several diseases associated with CNS dysfunction including Alzheimer’s disease, Parkinson’s disease, schizophrenia, depression or sleeping disorders. A description of target enzymes (e.g., -secretase, γ-secretase, fatty acid amide hydrolase – FAAH, leucine-rich repeat kinase 2 – LRRK2) and selected receptors (e.g., GABA-A, histamine H3, serotonin 5-HT3, 5-HT4, 5-HT6, dopamine D4, adenosine A2A, orexin receptor), modes of action of imidazopyridine-based ligands and their therapeutic importance is discussed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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