Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151960" target="_blank" >RIV/61989592:15310/14:33151960 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/14:33151960
Result on the web
<a href="http://pubs.acs.org/doi/pdf/10.1021/co500090t" target="_blank" >http://pubs.acs.org/doi/pdf/10.1021/co500090t</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/co500090t" target="_blank" >10.1021/co500090t</a>

Result language
angličtina
Original language name
Directed Solid-Phase Synthesis of Trisubstituted Imidazopyridines and Imidazopyridines
Original language description
An efficient solid-supported method for the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine is described. The key pyridine building block was reacted with polymer-supported amines, followed by the replacement of the second chlorine with amines, nitro group reduction and imidazole ring closure with aldehydes. Depending on the combination of polymer-supported and solution-phase reagents, the strategy allowed for the simple preparation of the target trisubstituted derivatives with variable positioning of the pyridine nitrogen atom. Additionally, after a slight modification of the method, the preparation of strictly isomeric imidazopyridines was possible.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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