Prediction of Thiopurine Metabolite Levels Based on Haematological and Biochemical Parameters
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73599084" target="_blank" >RIV/61989592:15110/19:73599084 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/19:00512143 RIV/00216208:11130/19:10400195 RIV/00098892:_____/19:N0000093 RIV/00064203:_____/19:10400195 RIV/61989592:15310/19:73599084
Result on the web
<a href="https://insights.ovid.com/crossref?an=00005176-201910000-00018" target="_blank" >https://insights.ovid.com/crossref?an=00005176-201910000-00018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MPG.0000000000002436" target="_blank" >10.1097/MPG.0000000000002436</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of Thiopurine Metabolite Levels Based on Haematological and Biochemical Parameters
Original language description
Objectives: Therapeutic drug monitoring of thiopurine erythrocyte levels is not available in all centers and it usually requires quite a long time to obtain the results. The aims of this study were to build a model predicting low levels of 6-thioguanine and 6-methylmercaptopurine in pediatric inflammatory bowel disease (IBD) patients and to build a model to predict nonadherence in patients treated with azathioprine (AZA). Methods: The study consisted of 332 observations in 88 pediatric IBD patients. Low AZA dosing was defined as 6-thioguanine levels <125 pmol/8 x 10(8) erythrocytes and 6-methylmercaptopurine levels <5700 pmol/8 x 10(8) erythrocytes. Nonadherence was defined as undetectable levels of 6-thioguanine and 6-methylmercaptopurine <240 pmol/8 x 10(8) erythrocytes. Data were divided into training and testing part. To construct the model predicting low 6-thioguanine levels, nonadherence, and the level of 6-thioguanine, the modification of random forest method with cross-validation and resampling was used. Results: The final models predicting low 6-thioguanine levels and nonadherence had area under the curve, 0.87 and 0.94; sensitivity, 0.81 and 0.82; specificity, 0.80 and 86; and distance, 0.31 and 0.21, respectively, when applied on the testing part of the dataset. When the final model for prediction of 6-thioguanine values was applied on testing dataset, a root-mean-square error of 110 was obtained. Conclusions: Using easily obtained laboratory parameters, we constructed a model with sufficient accuracy to predict patients with low 6-thioguanine levels and a model for prediction of AZA treatment nonadherence (web applications: https://hradskyo.shinyapps.io/6TG_prediction/ and https://hradskyo.shinyapps.io/Non_adherence/).
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
—
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
ISSN
0277-2116
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"E105"-"E110"
UT code for WoS article
000506845100003
EID of the result in the Scopus database
2-s2.0-85072193210