CDKN1A Gene Expression in Two Multiple Myeloma Cell Lines With Different P53 Functionality
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73601501" target="_blank" >RIV/61989592:15110/20:73601501 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/20:N0000042
Result on the web
<a href="https://obd.upol.cz/id_publ/333181387" target="_blank" >https://obd.upol.cz/id_publ/333181387</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.14501" target="_blank" >10.21873/anticanres.14501</a>
Alternative languages
Result language
angličtina
Original language name
CDKN1A Gene Expression in Two Multiple Myeloma Cell Lines With Different P53 Functionality
Original language description
BACKGROUND/AIM: Multiple myeloma is a highly heterogeneous disease of clonal plasma cells. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their precise mechanisms of actions are not well understood. MATERIALS AND METHODS: Cell-cycle regulation and pro-apoptotic effects of two histone deacetylase inhibitors, suberohydroxamic acid (SAHA) and suberoylanilide hydroxamic acid (SBHA), were analyzed in multiple myeloma cell lines RPMI8226 and U266 with differing TP53 status using gene-expression analysis. RESULTS: Enhanced expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21WAF/CIP1) detected in the TP53-deleted U266 cell line after SAHA treatment indicates the P53-independent mode of transcriptional activation of CDKN1A gene. In contrast, CDKN1A gene expression was significantly increased by both SBHA and SAHA treatment of TP53-mutated RPMI8226 cells. CONCLUSION: SAHA appears to be a potentially effective pro-apoptotic and anticancer drug with universal application in the treatment of heterogeneous populations of multiple myeloma cells. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANTICANCER RESEARCH
ISSN
0250-7005
e-ISSN
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Volume of the periodical
40
Issue of the periodical within the volume
9
Country of publishing house
GR - GREECE
Number of pages
9
Pages from-to
4979-4987
UT code for WoS article
000568990100003
EID of the result in the Scopus database
2-s2.0-85090260979