Siderophore-Based Molecular Imaging of Fungal and Bacterial Infections-Current Status and Future Perspectives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73602592" target="_blank" >RIV/61989592:15110/20:73602592 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2309-608X/6/2/73/htm" target="_blank" >https://www.mdpi.com/2309-608X/6/2/73/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jof6020073" target="_blank" >10.3390/jof6020073</a>

Result language
angličtina
Original language name
Siderophore-Based Molecular Imaging of Fungal and Bacterial Infections-Current Status and Future Perspectives
Original language description
Iron is an indispensable metal for virtually all organisms. During infection, pathogens typically encounter iron limitation as the host iron is tightly sequestered by host proteins such as hemoglobin, transferrin, lactoferrin, and ferritin and iron–sulfur cluster proteins [1]. Consequently, pathogens evolved strategies to capture iron from the host sources. Aspergillus fumigatus employs two high-affinity iron acquisition mechanisms: reductive iron assimilation and siderophore-mediated iron acquisition [2]. Both systems are induced by iron starvation in vitro as well as in vivo in a murine model of pulmonary aspergillosis [3,4].
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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