Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73607380" target="_blank" >RIV/61989592:15110/21:73607380 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S001448862100162X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001448862100162X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.expneurol.2021.113756" target="_blank" >10.1016/j.expneurol.2021.113756</a>

Result language

angličtina

Original language name

Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies

Original language description

Alzheimer&apos;s disease (AD) is characterised by the accumulation of intracytoplasmic aggregates of tau protein, which are suggested to spread in a prion-like manner between interconnected brain regions. This spreading is mediated by the secretion and uptake of tau from the extracellular space or direct cell-to-cell transmission through cellular protrusions. The prion-like tau then converts the endogenous, normal tau into pathological forms, resulting in neurodegeneration. The endoplasmic reticulum/Golgi-independent tau secretion through unconventional secretory pathways involves delivering misfolded and aggregated tau to the plasma membrane and its release into the extracellular space by non-vesicular and vesicular mechanisms. Although cytoplasmic tau was thought to be released only from degenerating cells, studies now show that cells constitutively secrete tau at low levels under physiological conditions. The mechanisms of secretion of tau under physiological and pathological conditions remain unclear. Therefore, a better understanding of these pathways is essential for developing therapeutic approaches that can target prion-like tau forms to prevent neurodegeneration progression in AD. This review focuses on unconventional secretion pathways involved in the spread of tau pathology in AD and presents these pathways as prospective areas for future AD drug discovery and development.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EXPERIMENTAL NEUROLOGY

ISSN

0014-4886

e-ISSN

—

Volume of the periodical

343

Issue of the periodical within the volume

113756

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

"nestránkováno"

UT code for WoS article

000679110400005

EID of the result in the Scopus database

2-s2.0-85106605913