Tau oligomers in sera of patients with Alzheimer’s disease and aged controls

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915413" target="_blank" >RIV/00023752:_____/17:43915413 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/17:43913180
Result on the web
<a href="http://content.iospress.com/articles/journal-of-alzheimers-disease/jad170048" target="_blank" >http://content.iospress.com/articles/journal-of-alzheimers-disease/jad170048</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-170048" target="_blank" >10.3233/JAD-170048</a>

Result language
angličtina
Original language name
Tau oligomers in sera of patients with Alzheimer’s disease and aged controls
Original language description
Although tau protein was long regarded as an intracellular protein with several functions inside the cell, new evidence has shown tau secretion into the extracellular space. The active secretion of tau could be a physiological response of neurons to increased intracellular amounts of tau during the progression of tau pathology. We looked for potential differences in the serum levels of toxic tau oligomers in regards to cognitive impairment of subjects. We detected tau oligomers in the serum of Alzheimer’s disease (AD) patients, but they were also present to some extent in the serum of healthy older subjects where the levels positively correlated with aging (Spearman r = 0.26, p = 0.016). On the contrary, we found lower levels of tau oligomers in the serum of mild cognitive impairment (MCI) (p = 0.033) and MCI-AD (p = 0.006) patients. These results could suggest that clearance of extracellular tau proteins takes place, in part, in the periphery. In the case of MCI patients, the lower levels of tau oligomers could be the result of impaired clearance of tau protein from interstitium to blood and consequent accumulation of tau aggregates in the brain.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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