Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919425" target="_blank" >RIV/00023752:_____/18:43919425 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/18:43916683
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0165572817305945" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165572817305945</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2018.05.004" target="_blank" >10.1016/j.jneuroim.2018.05.004</a>
Alternative languages
Result language
angličtina
Original language name
Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients
Original language description
The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: 1) against three various tau antigens 2) between AD patients, MCI and other dementias and cognitively normal individuals 3) to find out if the antibody levels are dependent on age and sex We observed higher reactivity of natural tau-reactive antibodies towards phosphorylated bovine tau protein than to human recombinant (non-phosphorylated) tau protein. Males with MCI-AD had higher amounts of these antibodies than corresponding controls. Concentrations of antibodies were lower in females with the MCI-AD than in control females. These findings may have implications for tau vaccination trials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroimmunology
ISSN
0165-5728
e-ISSN
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Volume of the periodical
322
Issue of the periodical within the volume
September
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000439674800001
EID of the result in the Scopus database
2-s2.0-85047218314