Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39900593" target="_blank" >RIV/00216275:25310/15:39900593 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/15:43914801 RIV/00216208:11120/15:43910767
Result on the web
<a href="http://dx.doi.org/10.1016/j.jneuroim.2015.10.017" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2015.10.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2015.10.017" target="_blank" >10.1016/j.jneuroim.2015.10.017</a>
Alternative languages
Result language
angličtina
Original language name
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product
Original language description
The latest therapeutic approaches to Alzheimer disease are using intravenous immunoglobulin (MG) products. Therefore, the detailed characterization of target-specific antibodies naturally occurring in MG products is beneficial. We have focused on characterization of antibodies isolated against tau protein, a biomarker of Alzheimer's disease, from Flebogamma IVIG product. The analysis of IgG subclass distribution indicated skewing toward IgG3 in anti-tau-enriched IgG fraction. The evaluation of their reactivity and avidity with several recombinant tau forms was performed by ELISA and blotting techniques. Truncated non-phosphotylated tau protein (amino acids 155-421) demonstrated the highest reactivity and avidity index. We provide the first detailed insight into the reactivity of isolated natural antibodies against tau protein.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroimmunology
ISSN
0165-5728
e-ISSN
—
Volume of the periodical
289
Issue of the periodical within the volume
October 28, 2015
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
121-129
UT code for WoS article
000366784500017
EID of the result in the Scopus database
—