Unravelling the genetic basis of sarcoidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73612548" target="_blank" >RIV/61989592:15110/22:73612548 - isvavai.cz</a>
Result on the web
<a href="https://www.ers-education.org/lr/show-details/?idP=254934" target="_blank" >https://www.ers-education.org/lr/show-details/?idP=254934</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/2312508X.10031320" target="_blank" >10.1183/2312508X.10031320</a>
Alternative languages
Result language
angličtina
Original language name
Unravelling the genetic basis of sarcoidosis
Original language description
Sarcoidosis is a heterogeneous disease with significant heritability and a significant proportion of familial disease, providing convincing evidence for a role of genetic factors in disease development. Numerous genes have been shown to be involved in the risk for disease development and its phenotypic manifestations. So far, strong genetic associations have been detected only for specific ethnic and phenotypic populations and involve the HLA class II-encoding peptides that are important for antigen recognition, and may thus be disease trigger related. Many of the genomic regions and genes that have been shown to associate with sarcoidosis significantly overlap with those identified for a wide spectrum of immune-mediated diseases, while only a few are specific for sarcoidosis or a phenotype of the disease. Although recent whole-exome sequencing approaches have not yet provided easily interpretable results, such unbiased deep-sequencing methods hold promise for further unravelling of the immunopathogenic pathways underlying the different disease entities in sarcoidosis.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
<a href="/en/project/NV18-05-00134" target="_blank" >NV18-05-00134: Immunogenetic molecular profile of sarcoidosis: significance for disease course prediction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Sarcoidosis (ERS Monograph)
ISBN
978-1-84984-145-0
Number of pages of the result
16
Pages from-to
41-56
Number of pages of the book
349
Publisher name
European Respiratory Society
Place of publication
Sheffield
UT code for WoS chapter
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