MCP-1-2518 (A/G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001920" target="_blank" >RIV/61989592:15110/05:00001920 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

MCP-1-2518 (A/G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis

Original language description

Background and aim: Genetic factors controlling production of chemotactic cytokines are thought to be important for development of inflammatory response in pulmonary sarcoidosis. Monocyte chemoattractant protein (MCP)-1/CCL2, a chemokine recruiting mononuclear cells, has been shown to play important role in sarcoidosis. A single nucleotide polymorphism of the MCP-1 gene promotor (-2518*A/G) has been associated with increased production of MCP-1 protein. This study, therefore, aimed at exploring relationship between this polymorphism and pulmonary sarcoidosis including Löfgren's syndrome (LS). Methods: The MCP-1-2518 genotypes were determined using polymerase chain reaction with sequence specific primers in 130 patients with sarcoidosis and 359 healthycontrol subjects. ELISA was used to detect serum (n=91) and BALF (n=57) MCP-1 protein level. Results: While no significant difference in the allele distribution between patients with sarcoidosis and healthy controls was observed (P=0.17),

Czech name

Vztah mezi MCP-1-2518 (A/G) a sarkoidózou u pacientů českého původu

Czech description

Práce sleduje vztah mezi MCP-1-2518 (A/G) a sarkoidózou u pacientů českého původu. Nezjistili jsme rozdíl v alelických frekvencích tohoto polymorfismu mezi pacienty se sarkoidózou (n=359) a zdravými kontrolními jedinci (n=359). Frekvence alely MCP-1-2518*G (p=0.01, relativní riziko, OR=2.3) a genotypu GG (p=0.03, OR=3.9) byla signifikantně zvýšená u pacientů s Löfgrenovým syndromem. Hladina proteinu MCP-1 v séru a BALF nekorelovala s MCP-1-2518 genotypem.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F05%2F2614" target="_blank" >GA310/05/2614: Expression-profiling of chemokine ligands and receptors in pulmonary sarcoidosis</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Respirace

ISSN

1211-572X

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

18

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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