Monocyte chemoattractant protein-1 in schizophrenia: 2518A/G genetic variant and protein levels in Armenian population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138671" target="_blank" >RIV/61989592:15110/12:33138671 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.cyto.2012.02.013" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2012.02.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cyto.2012.02.013" target="_blank" >10.1016/j.cyto.2012.02.013</a>

Result language

angličtina

Original language name

Monocyte chemoattractant protein-1 in schizophrenia: 2518A/G genetic variant and protein levels in Armenian population

Original language description

Monocyte chemoattractant protein-1 (MCP-1) has been proposed as a contributory factor in pathophysiology of schizophrenia. The aim of the current study was to explore the possible association of the MCP-1-2518A/G genetic polymorphism and plasma levels ofMCP-1 in patients with paranoid schizophrenia. The MCP-1-2518A/G (rs1024611) polymorphism and blood levels of MCP-1 in patients with paranoid schizophrenia and healthy subjects were evaluated and compared. One hundred and three chronic patients with paranoid schizophrenia treated with neuroleptics and 105 healthy subjects were genotyped using polymerase chain reaction with sequence-specific primers (PCR-SSP) and their MCP-1 plasma levels were measured by a solid-phase enzyme-linked immunosorbent assay(ELISA). When comparisons were made between patients and controls, the frequency of the MCP-1-2518*G minor allele (35% vs 23%, p=0.009, OR=1.77, 95% CI: 1.1-2.04) and also of the MCP-1-2518*G carriers (60% vs 40%, p=0.003, OR=2.27, 95% CI

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicine for regional development and human resources</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytokine

ISSN

1043-4666

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

351-354

UT code for WoS article

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EID of the result in the Scopus database

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