Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73612826" target="_blank" >RIV/61989592:15110/22:73612826 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/22:73612826
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/8/4168/htm" target="_blank" >https://www.mdpi.com/1422-0067/23/8/4168/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms23084168" target="_blank" >10.3390/ijms23084168</a>
Alternative languages
Result language
angličtina
Original language name
Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs
Original language description
Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. It has many endogenous and exogenous inducers, and is closely connected with age, age-related pathologies, DNA damage, degenerative disorders, tumor suppression and activation, wound healing, and tissue repair. However, the literature is replete with contradictory findings concerning its triggering mechanisms, specific biomarkers, and detection protocols. This may be partly due to the wide range of cellular and in vivo animal or human models of accelerated aging that have been used to study senescence and test senolytic drugs. This review summarizes recent findings concerning senescence, presents some widely used cellular and animal senescence models, and briefly describes the best-known senolytic agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
26
Pages from-to
4168
UT code for WoS article
000786807500001
EID of the result in the Scopus database
2-s2.0-85127863967