Altered Plasma, Urine, and Tiissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73615455" target="_blank" >RIV/61989592:15110/22:73615455 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2072-6694/14/19/4622" target="_blank" >https://www.mdpi.com/2072-6694/14/19/4622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers14194622" target="_blank" >10.3390/cancers14194622</a>

Result language

angličtina

Original language name

Altered Plasma, Urine, and Tiissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Original language description

Simple Summary: Renal cell carcinoma (RCC) is among the most common cancer types in both men and women, and its early detection significantly improves survival. Minimally-invasive blood- or urine-based tests may increase the RCC detection rate, especially before patients develop symptoms. Here, we report significant changes in concentrations of sulfatides and sphingomyelins in plasma and urine in RCC patients compared to healthy controls. For the first time, we present findings that similar alterations appear in the lipid profiles of body fluids and tissues in patients. We observe gradual changes in sulfatide and sphingomyelin concentrations with increasing tumor stage andgrade. We built binary classifiers that detect RCC based on plasma and urine lipidome dysregulationsand we show that the plasma lipidome alterations enable distinguishing between early-stage RCC and controls. Our results demonstrate the considerable potential of lipid screening in biofluids for RCC detection and monitoring in clinical settings.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA18-12204S" target="_blank" >GA18-12204S: Characterization of human lipidome and metabolome for personalized healthcare and biomarker discovery: case study of kidney cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

19

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

4622

UT code for WoS article

000866701300001

EID of the result in the Scopus database

2-s2.0-85139932391