Lipid messengerphosphatidylinositol-4,5-bisphosphate is increased by both PPARα activators and inhibitors: relevance for intestinal cell differentiation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73617618" target="_blank" >RIV/61989592:15110/22:73617618 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2079-7737/11/7/997" target="_blank" >https://www.mdpi.com/2079-7737/11/7/997</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biology11070997" target="_blank" >10.3390/biology11070997</a>
Alternative languages
Result language
angličtina
Original language name
Lipid messengerphosphatidylinositol-4,5-bisphosphate is increased by both PPARα activators and inhibitors: relevance for intestinal cell differentiation
Original language description
Fibrates, such as fenofibrate, are widely used drugs for dyslipidaemia treatment. It is known that they activate peroxisome proliferator-activated receptor α (PPARα) which serves as a lipid sensor in the organism. This article addresses how activators and inhibitor of the PPARα could affect differentiation of intestinal cells. Carcinogenesis is a disruption of normal differentiation process and colorectal carcinoma is the third most common cancer in terms of incidence, but the secondp in terms of mortality. One of the important signalling pathways in intestinal cell differentiation as well as carcinogenesis is PI3K/Akt/PTEN. We showed that PPARα activators as well as inhibitor affected the levels of one member of this pathway called phosphatidylinositol-4,5-bisphosphate. This molecule is important for formation of microvilli, the essential structures of fully differentiated intestinal cells.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biology
ISSN
2079-7737
e-ISSN
2079-7737
Volume of the periodical
11
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
997
UT code for WoS article
000831722600001
EID of the result in the Scopus database
2-s2.0-85133529539