Innate Immune Response in Hypertension
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73617624" target="_blank" >RIV/61989592:15110/22:73617624 - isvavai.cz</a>
Result on the web
<a href="https://www.eurekaselect.com/article/126523" target="_blank" >https://www.eurekaselect.com/article/126523</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1381612828666220922112412" target="_blank" >10.2174/1381612828666220922112412</a>
Alternative languages
Result language
angličtina
Original language name
Innate Immune Response in Hypertension
Original language description
Even though an association between inflammation and hypertension has been known for many years, it has not been simple to ascertain the role of several physiological responses involved. The innate immune response plays a critical role in these physiological responses. Innate immune cells can be activated directly by shear stress, activate the inflammasome and produce numerous cytokines and soluble mediators essential in hypertension. NFkB activation is mainly involved in the activation of innate immune cells. Shear stress also stimulates the expression of DAMP and PAMP receptors, enhancing pathogen and danger signals and magnifying inflammation. The adaptative immune response is activated with the increased antigen presentation resulting from the insults mentioned. Chronic inflammation may lead to autoimmunity. Peripheral hypoxia, a consequence of hypertension, activates hypoxia-inducing factors 1-alpha and 1-beta (HIF-1 alpha, HIF-1 beta), which modulate innate immune cells and promote inflammation. HIF-1 alpha is involved in the upregulation of oxygen and nitrogen radical production proteins. HIF-1 beta down-regulates antioxidant enzymes. However, the critical evidence of the role of innate immune cells in hypertension came from the results of clinical trials involving therapies blocking inflammatory cytokines and Toll-like receptor expression. Several lines of research have been conducted on this complex disease. Pro-tolerogenic innate immune cells, myeloid suppressor cells, and M2 macrophages may play a crucial role in promoting or resolving inflammation, cardiovascular diseases and hypertension, and should be studied in detail.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CURRENT PHARMACEUTICAL DESIGN
ISSN
1381-6128
e-ISSN
1873-4286
Volume of the periodical
28
Issue of the periodical within the volume
36
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
7
Pages from-to
2984-2990
UT code for WoS article
000892876800005
EID of the result in the Scopus database
2-s2.0-85141400377