Population pharmacokinetic model-based dosing proposal for ampicillin prophylaxis in cardiac surgery patients with cardiopulmonary bypass

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73620560" target="_blank" >RIV/61989592:15110/23:73620560 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10457862 RIV/00098892:_____/23:10158502 RIV/00064165:_____/23:10457862

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/1120009X.2023.2170895?scroll=top&needAccess=true" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/1120009X.2023.2170895?scroll=top&needAccess=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1120009X.2023.2170895" target="_blank" >10.1080/1120009X.2023.2170895</a>

Result language

angličtina

Original language name

Population pharmacokinetic model-based dosing proposal for ampicillin prophylaxis in cardiac surgery patients with cardiopulmonary bypass

Original language description

The aim of this study was to describe and quantify pharmacokinetics of ampicillin used prophylactically in cardiac surgery both with and without cardiopulmonary bypass (CPB) using population pharmacokinetic analysis in order to propose an optimal dosing strategy. Adult patients undergoing cardiac surgery and treated with prophylactic dose of 2 g ampicillin were enrolled to this prospective study. Blood samples were collected according to the study protocol and ampicillin plasma concentrations were measured using HPLC/UV system. A three-stage population pharmacokinetic model using nonlinear mixed-effects modelling approach was developed. Totally 273 blood samples obtained from 20 patients undergoing cardiac surgery with the use of the CPB and 20 patients without CPB use were analyzed. Two-comparmental model best fits ampicillin concentration-time data. Mean ± SD body weight-normalized ampicillin central and peripheral volume of distribution was 0.12 ± 0.02 L/kg and 0.15 ± 0.03 L/kg, respectively, while mean ± SD ampicillin clearance in typical patient with eGFR of 1.5 mL/s/1.73 m2 was 1.17 ± 0.05 L/h. The use of CPB did not significantly affect the pharmacokinetics of ampicillin. When administering 2 g of ampicillin before surgery, an additional dose should be administered to reach the PK/PD target of fT &gt; MIC = 50% if the operation lasts longer than 430 min in patients with moderate to severe renal impairment, 320 min in patients with mild renal impairment, 220 min in patients with normal renal function status or 140 min in patients with an augmented renal clearance.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/NV17-31540A" target="_blank" >NV17-31540A: Population pharmacokinetics of antibiotic prophylaxis during cardiac surgery with cardiopulmonary bypass</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF CHEMOTHERAPY

ISSN

1120-009X

e-ISSN

1973-9478

Volume of the periodical

35

Issue of the periodical within the volume

7

Country of publishing house

IT - ITALY

Number of pages

9

Pages from-to

614-622

UT code for WoS article

000919443500001

EID of the result in the Scopus database

2-s2.0-85147304566