Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73618311" target="_blank" >RIV/61989592:15110/23:73618311 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10445262 RIV/00098892:_____/23:10157474 RIV/00064165:_____/23:10445262
Result on the web
<a href="https://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=3276&type=fin&ver=2" target="_blank" >https://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=3276&type=fin&ver=2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2022.033" target="_blank" >10.5507/bp.2022.033</a>
Alternative languages
Result language
angličtina
Original language name
Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation
Original language description
Aims: The aim of this pharmacokinetic study was to describe and quantify population pharmacokinetics of three antibiotics, cefazolin, ampicillin, and ciprofloxacin, used as antibacterial prophylaxis during cardiovascular surgery with the use of extracorporeal circulation (ECC). Methods: Adult patients undergoing cardiac surgery with ECC were enrolled to this prospective, pharmacokinetic study. An intravenous bolus of 2 g of ampicillin, 2 g of cefazolin or 400 mg of ciprofloxacin was administered 60-30 min before surgery. Blood samples were collected at 15, 30, 45, 60, 120 and 180 min after the administration and at the end of the surgery. Plasma concentrations of the antibiotics were measured using HPLC methods. Serum concentration-time profiles were analyzed using nonlinear mixed-effects modeling approach. Results: A total of 54 patients were enrolled into the study, 20 with ampicillin, 25 cefazolin and 9 ciprofloxacin. For all antibiotics, population pharmacokinetic models have been successfully developed. Conclusion: We identified estimated glomerular filtration rate (eGFR) as the main factor determining the achievement of the pharmacokinetic/pharmacodynamic (PK/PD) target in ampicillin or cefazolin and body weight in ciprofloxacin prophylaxis during cardiac surgery with ECC support.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV17-31540A" target="_blank" >NV17-31540A: Population pharmacokinetics of antibiotic prophylaxis during cardiac surgery with cardiopulmonary bypass</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOMEDICAL PAPERS-OLOMOUC
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
167
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
208-211
UT code for WoS article
000822732200001
EID of the result in the Scopus database
2-s2.0-85147292776