All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73618311" target="_blank" >RIV/61989592:15110/23:73618311 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/23:10445262 RIV/00098892:_____/23:10157474 RIV/00064165:_____/23:10445262

  • Result on the web

    <a href="https://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=3276&type=fin&ver=2" target="_blank" >https://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=3276&type=fin&ver=2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2022.033" target="_blank" >10.5507/bp.2022.033</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation

  • Original language description

    Aims: The aim of this pharmacokinetic study was to describe and quantify population pharmacokinetics of three antibiotics, cefazolin, ampicillin, and ciprofloxacin, used as antibacterial prophylaxis during cardiovascular surgery with the use of extracorporeal circulation (ECC). Methods: Adult patients undergoing cardiac surgery with ECC were enrolled to this prospective, pharmacokinetic study. An intravenous bolus of 2 g of ampicillin, 2 g of cefazolin or 400 mg of ciprofloxacin was administered 60-30 min before surgery. Blood samples were collected at 15, 30, 45, 60, 120 and 180 min after the administration and at the end of the surgery. Plasma concentrations of the antibiotics were measured using HPLC methods. Serum concentration-time profiles were analyzed using nonlinear mixed-effects modeling approach. Results: A total of 54 patients were enrolled into the study, 20 with ampicillin, 25 cefazolin and 9 ciprofloxacin. For all antibiotics, population pharmacokinetic models have been successfully developed. Conclusion: We identified estimated glomerular filtration rate (eGFR) as the main factor determining the achievement of the pharmacokinetic/pharmacodynamic (PK/PD) target in ampicillin or cefazolin and body weight in ciprofloxacin prophylaxis during cardiac surgery with ECC support.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    <a href="/en/project/NV17-31540A" target="_blank" >NV17-31540A: Population pharmacokinetics of antibiotic prophylaxis during cardiac surgery with cardiopulmonary bypass</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BIOMEDICAL PAPERS-OLOMOUC

  • ISSN

    1213-8118

  • e-ISSN

    1804-7521

  • Volume of the periodical

    167

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    4

  • Pages from-to

    208-211

  • UT code for WoS article

    000822732200001

  • EID of the result in the Scopus database

    2-s2.0-85147292776