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Challenges of in situ hybridization in miRNA analysis of triple-negative breast cancer morphological diversity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73622909" target="_blank" >RIV/61989592:15110/23:73622909 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/23:10158328

  • Result on the web

    <a href="http://www.elis.sk/download_file.php?product_id=7984&session_id=g6874af8plegej0p8k17jsqs42" target="_blank" >http://www.elis.sk/download_file.php?product_id=7984&session_id=g6874af8plegej0p8k17jsqs42</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/neo_2023_220519N533" target="_blank" >10.4149/neo_2023_220519N533</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Challenges of in situ hybridization in miRNA analysis of triple-negative breast cancer morphological diversity

  • Original language description

    miRNA expression in triple-negative breast cancers (TNBC) has mainly been studied from a methodological viewpoint.However, it has not been considered that miRNA expression profile may be associated with a specific morphological entityinside every tumor. The verification of this hypothesis on a set of 25 TNBCs was the subject of our previous work, wherewe confirmed specific expression of the studied miRNAs in 82 samples of different morphologies including inflammatoryinfiltrate, spindle cell, clear cell, and metastases after RNA extraction and purification as well as microchip and biostatistical analysis. In the current work, we demonstrate a low suitability of in situ hybridization method for miRNA detectioncompared to RT-qPCR, and in detail discuss the biological role of 8 miRNAs with the most significant changes of expression.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30224 - Radiology, nuclear medicine and medical imaging

Result continuities

  • Project

    <a href="/en/project/NV16-31997A" target="_blank" >NV16-31997A: Diagnostic and prognostic impact of miRNA expression profiles related to morphological heterogeneity in triple-negative breast cancer</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    NEOPLASMA

  • ISSN

    0028-2685

  • e-ISSN

    1338-4317

  • Volume of the periodical

    70

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    9

  • Pages from-to

    179-187

  • UT code for WoS article

    001070933100001

  • EID of the result in the Scopus database

    2-s2.0-85160206806