Exploring Phthalimide as the Acid Component in the Passerini Reaction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73624805" target="_blank" >RIV/61989592:15110/24:73624805 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/24:73624805
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.orglett.3c03962" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.orglett.3c03962</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.3c03962" target="_blank" >10.1021/acs.orglett.3c03962</a>

Result language
angličtina
Original language name
Exploring Phthalimide as the Acid Component in the Passerini Reaction
Original language description
Multicomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries. Despite the effectiveness of the Passerini reaction, the limited alternatives to the crucial carboxylic acid component pose a structural constraint. Here, we have discovered that the phthalimide moiety and its derivatives react in the Passerini reaction as an acid component. We explored their potential in synthesizing diverse and intricate molecules. The phthalimide moiety stands out as a favorable building block due to its oxidative stability, heat-stable characteristics, and resistance to solvents. Our approach introduces a novel perspective to multicomponent reactions by incorporating NH-based acid components, addressing the ongoing need for the development of innovative molecular scaffolds.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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