Synthesis and photo-induced anticancer activity of new 2-phenylethenyl-1H-benzo[e]indole dyes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73625642" target="_blank" >RIV/61989592:15110/24:73625642 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73625642
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0223523424006585" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0223523424006585</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2024.116777" target="_blank" >10.1016/j.ejmech.2024.116777</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and photo-induced anticancer activity of new 2-phenylethenyl-1H-benzo[e]indole dyes
Original language description
Herein, a series of new 1,1,2-trimethyl-1H-benzo[e]indole dyes was prepared via Knoevenagel condensation reaction between 1,1,2-trimethyl-1H-benzo[e]indole and benzaldehydes, and characterized using various spectroscopic methods. The obtained compounds showed cytotoxic properties in G361 melanoma cell line upon irradiation with 414 nm blue light at submicromolar doses. The mechanism of action of the most potent compound 15 was further investigated. The treatment induced substantial generation of reactive oxygen species, leading to DNA damage followed by cell death depending on the concentration of the photosensitizer compound and the irradiation intensity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN
0223-5234
e-ISSN
1768-3254
Volume of the periodical
277
Issue of the periodical within the volume
NOV
Country of publishing house
FR - FRANCE
Number of pages
14
Pages from-to
"116777-1"-"116777-14"
UT code for WoS article
001306566400001
EID of the result in the Scopus database
2-s2.0-85201598125