Prognostic relevance of the C-X-C motif chemokine ligand 13 and interleukin-8 in predicting the transition from clinically isolated syndrome to multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73626122" target="_blank" >RIV/61989592:15110/24:73626122 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/24:10158769

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ejn.16300" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ejn.16300</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ejn.16300" target="_blank" >10.1111/ejn.16300</a>

Result language

angličtina

Original language name

Prognostic relevance of the C-X-C motif chemokine ligand 13 and interleukin-8 in predicting the transition from clinically isolated syndrome to multiple sclerosis

Original language description

Prognostic relevance of the C-X-C motif chemokine ligand 13 and interleukin-8 in predicting the transition from clinically isolated syndrome to multiple sclerosisR42 Anotace anglickyThe initial phase of multiple sclerosis (MS), often known as clinically isolated syndrome (CIS), is a critical period for identifying individuals at high risk of progressing to full-blown MS and initiating timely treatment. In this study, we aimed to evaluate the prognostic value of C-X-C motif chemokine ligand 13 (CXCL13) and interleukin-8 (IL-8) as potential markers for CIS patients&apos; conversion to MS. Our study encompassed patients with CIS, those with relapsing–remitting MS (RRMS), and control subjects, with sample analysis conducted on both cerebrospinal fluid (CSF) and serum. Patients were categorized into four groups: CIS–CIS (no MS development within 2 years), CIS–RRMS (conversion to RRMS within 2 years), RRMS (already diagnosed), and a control group (CG) with noninflammatory central nervous system disorders. Results showed significantly elevated levels of CXCL13 in CSF across all patient groups compared with the CG (p &lt; 0.0001, Kruskal–Wallis test). Although CXCL13 concentrations were slightly higher in the CIS–RRMS group, statistical significance was not reached. Similarly, significantly higher levels of IL-8 were detected in CSF samples from all patient groups compared with the CG (p &lt; 0.0001, Kruskal–Wallis test). Receiver operating characteristic analysis in the CIS–RRMS group identified both CXCL13 (area under receiver operating characteristic curve = .959) and IL-8 (area under receiver operating characteristic curve = .939) in CSF as significant predictors of CIS to RRMS conversion. In conclusion, our study suggests a trend towards elevated CSF IL-8 and CSF CXCL13 levels in CIS patients progressing to RRMS. These findings emphasize the importance of identifying prognostic markers to guide appropriate treatment strategies for individuals in the early stages of MS.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV19-05-00191" target="_blank" >NV19-05-00191: Importance of non-spiral forms of Borrelia burgdorferi spirochetes in the pathogenesis of Lyme borreliosis and post-Lyme disease syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EUROPEAN JOURNAL OF NEUROSCIENCE

ISSN

0953-816X

e-ISSN

1460-9568

Volume of the periodical

59

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

2955-2966

UT code for WoS article

001181092000001

EID of the result in the Scopus database

2-s2.0-85187100756