Cerebrospinal fluid and serum levels of interleukin-8 in patients with multiple sclerosis and its correlation with Q-albumin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73583294" target="_blank" >RIV/61989592:15110/17:73583294 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/17:N0000016

Result on the web

<a href="http://dx.doi.org/10.1016/j.msard.2017.03.007" target="_blank" >http://dx.doi.org/10.1016/j.msard.2017.03.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msard.2017.03.007" target="_blank" >10.1016/j.msard.2017.03.007</a>

Result language

angličtina

Original language name

Cerebrospinal fluid and serum levels of interleukin-8 in patients with multiple sclerosis and its correlation with Q-albumin

Original language description

Abstract INTRODUCTION: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS). Autoimmune inflammation is common in the early stages of MS and is followed by neurodegenerative processes. The result of these changes is axon and myelin breakdown. The paraclinical examination methods are an important part of the diagnostic process. Magnetic resonance imaging of the brain and the cervical spinal cord and an examination of cerebrospinal fluid (CSF) are common paraclinical examinations. An increasing number of studies deal with CSF and serum levels of biomarkers and their role in MS. We hypothesized that the level of interleukin-8 (IL-8) could be different in MS patients than in controls. These differences may be related to damage of the blood-brain barrier (BBB). BBB damage is quantified by the quotient of albumin (Q-alb). METHODS: CSF and serum levels of IL-8 were assessed in 102 patients with newly diagnosed MS meeting McDonald&apos;s revised diagnostic criteria and in 102 subjects as a control group. We then correlated these results with Q-alb. RESULTS: Levels of IL-8 in CSF were significantly higher in MS patients than in controls (Mann-Whitney U test, p&lt;0.0001). Serum levels of IL-8 were significantly lower in MS patients than in controls (Mann-Whitney U test, p=0.018). Spearman&apos;s correlation analysis proved a significant correlation between levels of IL-8 and Q-alb. CONCLUSION: As the etiology of MS is only partially known, research dealing with biomarkers in MS should continue. Better knowledge of etiology can provide a new perspective, especially for treatment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multiple Sclerosis and Related Disorders

ISSN

2211-0348

e-ISSN

—

Volume of the periodical

2017

Issue of the periodical within the volume

14

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

12-15

UT code for WoS article

000405049900005

EID of the result in the Scopus database

2-s2.0-85015771034