Sequential analysis of biomarkers in cerebrospinal fluid and serum during invasive meningococcal disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A5388" target="_blank" >RIV/00216208:11110/09:5388 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/09:00001717 RIV/00064211:_____/09:#0000065

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sequential analysis of biomarkers in cerebrospinal fluid and serum during invasive meningococcal disease

Original language description

The aim of the present study was to determine the profile of different inflammatory molecules in serum and cerebrospinal fluid (CSF) during invasive meningococcal disease (IMD). Paired serum and CSF samples were obtained at the time of diagnostic and follow-up lumbar puncture and were examined using Luminex analysis. IMD severity correlated with serum interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) on admission. Furthermore, the CSF levels of IL-1 beta, IL-1ra, IL-6, IL-8, macrophageinflammatory protein-1 beta (MIP-1 beta), and monocyte chemoattractant protein-1 (MCP-1) were significantly higher than their respective serum levels. The strongest correlations were found between serum concentrations of IL-1 beta and IL-1ra, IL-6, IL-8, and MIP-1 beta, whereas the strongest correlations in CSF were found between endotoxin and IL-8, IL-17, MIP-1 beta, and MCP-1. Sequential multiple analyses revealed patterns of inflammatory responses that were associated with the severi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NR9316" target="_blank" >NR9316: Use of immune markers including expression of Toll-like receptors in early diagnosis of bacterial origin of sepsis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Clinical Microbiology of Infectious Diseases

ISSN

0934-9723

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

000266814700009

EID of the result in the Scopus database

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