Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00057528" target="_blank" >RIV/00216224:14110/12:00057528 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/12:43871334

Result on the web

<a href="http://dx.doi.org/10.1016/j.phymed.2012.04.001" target="_blank" >http://dx.doi.org/10.1016/j.phymed.2012.04.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.phymed.2012.04.001" target="_blank" >10.1016/j.phymed.2012.04.001</a>

Result language

angličtina

Original language name

Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line

Original language description

vQuaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine have been used in folk medicine for their wide range of useful properties. One of their major effect is also anti-inflammatory activity, that is not clarified in detail. This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha ), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1 beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. The effect of these alkaloids was compared with that of conventional drug prednisone. Human monocyte-derived macrophages were pre-treated with alkaloids or prednisone and inflammatory reaction wasinduced by lipopolysaccharide. Changes of gene expression at the transcriptional level of mentioned cytokines were measured. In our study mainly affected pro-inflammatory cytokines were CCL-2 and IL-6.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA525%2F08%2F0819" target="_blank" >GA525/08/0819: Plant sources of minor benzophenanthridine alkaloids and study of their interaction with DNA</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytomedicine

ISSN

0944-7113

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

890-895

UT code for WoS article

000309640600006

EID of the result in the Scopus database

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