The effect of cytokines produced by human adipose tissue on monocyte adhesion to the endothelium
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078395" target="_blank" >RIV/00023001:_____/19:00078395 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10408776
Result on the web
<a href="https://www.tandfonline.com/doi/pdf/10.1080/19336918.2019.1644856?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/pdf/10.1080/19336918.2019.1644856?needAccess=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/19336918.2019.1644856" target="_blank" >10.1080/19336918.2019.1644856</a>
Alternative languages
Result language
angličtina
Original language name
The effect of cytokines produced by human adipose tissue on monocyte adhesion to the endothelium
Original language description
Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro-inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were tested using adipose tissue-conditioned media (ATCM) prepared by culturing human VAT. The cytokines concentrations in ATCM, the cytokines expression and adhesion molecules in stimulated ECs were measured. The concentrations of IL-1 beta,TNF-alpha,MCP-1,IL-10,and RANTES measured in ATCM correlated positively with monocyte adhesiveness to ECs. Additionally, ATCM increased the adhesion molecules (ICAM-1, VCAM-1) gene expression. Selective inhibitors highlighted the importance of IL-1 beta and TNF-alpha in the process by a significant decrease in monocyte adhesion compared to ATCM preconditioning without inhibitors. Human VAT significantly increased monocyte adhesion to ECs. It was significantly influenced by IL-1 beta, TNF-alpha, MCP-1, IL-10, and RANTES, with IL-1 beta and TNF-alpha having the strongest impact.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell adhesion and migration
ISSN
1933-6918
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
293-302
UT code for WoS article
000485070900001
EID of the result in the Scopus database
2-s2.0-85075981010