Hodgkin/Reed-Sternberg cells induce GPNMB expression and release from macrophages to suppress T-cell responses to the Epstein-Barr virus-encoded LMP2A protein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73632840" target="_blank" >RIV/61989592:15110/25:73632840 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/25:10158917
Result on the web
<a href="https://haematologica.org/article/view/haematol.2024.285319" target="_blank" >https://haematologica.org/article/view/haematol.2024.285319</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2024.285319" target="_blank" >10.3324/haematol.2024.285319</a>
Alternative languages
Result language
angličtina
Original language name
Hodgkin/Reed-Sternberg cells induce GPNMB expression and release from macrophages to suppress T-cell responses to the Epstein-Barr virus-encoded LMP2A protein
Original language description
Classical Hodgkin lymphoma (cHL) is characterized by the presence of Hodgkin-Reed-Sternberg (HRS) cells surrounded by a prominent inflammatory tumor microenvironment (TME). Although the TME is thought to prevent immune recognition of HRS cells by tumor-specific T cells, the mechanisms responsible are poorly understood. Here, we show that tumor-associated macrophages (TAM) in the TME of cHL strongly express glycoprotein non-metastatic B (GPNMB). Co-culture with cHL cell lines induced the M2 polarization of macrophages, which was accompanied by increased surface expression of GPNMB and its release as a soluble form. Importantly, soluble recombinant GPNMB (rGPNMB) inhibited CD8+ T-cell recognition of Epstein-Barr virus (EBV)-derived tumor epitopes in cHL cells, suggesting that inhibiting GPNMB in the cHL TME could enhance anti-tumor immune responses. cHL is characterized by single malignant HRS cells surrounded by a pro-inflammatory tumor microenvironment (TME) that supports HRS cell survival, growth and immune escape. The EBV genome is present in HRS cells in 30-50% of cHL and expresses the immunologically subdominant EBV latent proteins, Epstein-Barr nuclear antigen 1 and latent membrane proteins, LMP1 and LMP2A.1 Cells expressing LMP1 and LMP2A are sensitive to lysis by EBV-specific cytotoxic CD8+ T cells in vitro. Moreover, EBV-specific CD8+ T cells have been shown to be present in the cHL TME. These data suggest that immune suppressive mechanisms operate in the TME of EBV+ cHL.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HAEMATOLOGICA
ISSN
0390-6078
e-ISSN
1592-8721
Volume of the periodical
110
Issue of the periodical within the volume
1
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
193-199
UT code for WoS article
001391817200021
EID of the result in the Scopus database
2-s2.0-85214300569