Fetal Sex Modulates Hofbauer Cells' Response to Diabetes in Human Placenta

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73633688" target="_blank" >RIV/61989592:15110/25:73633688 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2227-9059/13/11/2606" target="_blank" >https://www.mdpi.com/2227-9059/13/11/2606</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines13112606" target="_blank" >10.3390/biomedicines13112606</a>

Result language

angličtina

Original language name

Fetal Sex Modulates Hofbauer Cells' Response to Diabetes in Human Placenta

Original language description

Hofbauer cells (HBCs) are fetal-origin macrophages in the placental villous stroma that contribute to immune tolerance at the feto-maternal interface. They predominantly display an M2 phenotype, characterized by CD206 expression. Using immunohistochemistry and morphometric analysis, we quantified HBCs, assessed CD206 intensity and morphology, and evaluated apoptotic body accumulation in placental villi. Comparisons were made among pregnancies complicated by type 1 diabetes mellitus (T1DM), gestational diabetes mellitus (GDM), and normoglycemic controls, as well as between male and female fetuses. Significant effects of maternal diabetes and fetal sex on CD206 intensity were observed ([diagnosis: F = 2773.00, p &lt; 0.0001; sex: F = 12.19, p = 0.0005]), with a strong interaction (F = 165.40, p &lt; 0.0001). In controls, CD206 intensity was higher in female than male fetuses (p &lt; 0.0001).Across groups, CD206 intensity decreased progressively from controls to GDM and T1DM, with a more pronounced reduction in females. Reduced CD206 was associated with elongation and irregular HBC morphology and increased IL-1 beta (r = -0.392, p = 0.003; r = -0.609, p &lt; 0.0001) suggesting less tolerogenic phenotype.For apoptotic bodies, significant main effects of maternal diabetes and fetal sex were detected ([diagnosis: F = 97.16, p &lt; 0.0001; sex: F = 15.88, p = 0.0001]). Accumulation increased progressively from controls to GDM and T1DM, with higher counts in males. Maternal diabetes is associated with reduced CD206 intensity, altered HBC morphology, and accumulation of apoptotic bodies in placental villi. Our results suggest greater HBC plasticity, potentially contributing to a tolerogenic placental environment in females.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicines

ISSN

2227-9059

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

2606

UT code for WoS article

001625762200001

EID of the result in the Scopus database

2-s2.0-105023077175