Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F14%3A33149356" target="_blank" >RIV/61989592:15120/14:33149356 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-014-1184-4" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1184-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1184-4" target="_blank" >10.1007/s00702-014-1184-4</a>

Result language

angličtina

Original language name

Lenticular nucleus hyperechogenicity in Wilson's disease reflects local copper, but not iron accumulation

Original language description

In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and iron, in the brain of WD patients has been reported. The present study was designed to elucidate whether LN hyperechogenicity in WD reflects accumulation of copper or iron. Post-mortem brains of 15 WD patients and one non-WD subject were studied with ultrasonography in an investigator-blinded fashion. LN hyperechogenicity was measured planimetrically by manual tracing as well as using digitized image analysis.The putaminal copper content was determined in samples of 11 WD brains and the non-WD brains using inductively coupled plasma mass spectrometry, and iron content was assessed using flame atomic absorption spectroscopy. LN was normal on ul

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

2014

Issue of the periodical within the volume

121 (10)

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

1273-1279

UT code for WoS article

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EID of the result in the Scopus database

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