The Mirror of Erised: a retrospective population-wide study of Czech all-cause mortality data by COVID-19 vaccination status
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15260%2F25%3A73634979" target="_blank" >RIV/61989592:15260/25:73634979 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/25:73634979
Result on the web
<a href="https://link.springer.com/article/10.1186/s12889-025-23619-x#Fun" target="_blank" >https://link.springer.com/article/10.1186/s12889-025-23619-x#Fun</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12889-025-23619-x" target="_blank" >10.1186/s12889-025-23619-x</a>
Alternative languages
Result language
angličtina
Original language name
The Mirror of Erised: a retrospective population-wide study of Czech all-cause mortality data by COVID-19 vaccination status
Original language description
BackgroundIn this study, we investigated the association between COVID-19 vaccination status and all-cause mortality (ACM) rate in the population of the Czech Republic between January 2020 and December 2022.MethodsIn this retrospective study based on official population-wide individual (record-level) data, we analyzed monthly ACM rates stratified by COVID-19 vaccination status, sex, and age. The ACM was compared to expected mortality based on pre-COVID data. The recipients of the Janssen vaccine were excluded from the study. The final dataset comprised N = 5,636,949 individuals from the Czech Republic, encompassing all residents born between 1925 and 1980 who were alive on January 1, 2020.ResultsMultiple peculiar patterns in ACM were revealed. The ACM of vaccinated individuals across several age cohorts was greatly diminished compared to the ACM of the unvaccinated, even in periods when virtually no COVID-19-related deaths were observed, suggesting a strong selection/indication bias. A similar drop in the ACM of newly vaccinated individuals was observed again during the booster campaign. With time from vaccination, the differences in ACM between groups with different vaccination statuses dwindled. Indication bias was observed at the beginning of the vaccination campaign when the frailest individuals were preferentially vaccinated.ConclusionsThe population-wide data strongly suggest the presence of selection/indication bias, warranting careful interpretation of vaccination effectiveness estimates derived from observational studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/EH22_008%2F0004583" target="_blank" >EH22_008/0004583: Research of Excellence on Digital Technologies and Wellbeing</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC PUBLIC HEALTH
ISSN
1471-2458
e-ISSN
1471-2458
Volume of the periodical
25
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
nestránkováno
UT code for WoS article
001526960400005
EID of the result in the Scopus database
2-s2.0-105010417635