Endogeneous inhibitor of amine oxidase from the seedlings of Phaseolus vulgaris

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F00%3A00001073" target="_blank" >RIV/61989592:15310/00:00001073 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Endogeneous inhibitor of amine oxidase from the seedlings of Phaseolus vulgaris

Original language description

Copper amine oxidases (Cu-AO, amine:O2 oxidoreductase) is the key enzyme in the catabolism of biogenic amines. Cu-AO are inhibited by a variety of diverse natural or synthetic substances but any endogenous inhibitor of Cu-AO regulating its activity in vivo has been unambiguously characterized. In our previous studies, we confirmed Cu-AO from etiolated seedling of white bean (Phaseolus vulgaris) to be inhibited by a naturally occurring low-molecular endogenous inhibitor. To enable a detailed chemical andenzymological characterization of the inhibitor, we designed a bioassay-directed fractionation scheme of the seedling extract on the preparative scale. The purified substance was characterized as a reversible non-competitive inhibitor of Cu-AO from Phaseolus vulgaris, Pisum sativum and Lathyrus sativus.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemické listy

ISSN

0009-2770

e-ISSN

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Volume of the periodical

94

Issue of the periodical within the volume

8

Country of publishing house

XX - stateless person

Number of pages

2

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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