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Endogeneous inhibitor of amine oxidase from the seedlings of Phaseolus vulgaris

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F00%3A00001073" target="_blank" >RIV/61989592:15310/00:00001073 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Endogeneous inhibitor of amine oxidase from the seedlings of Phaseolus vulgaris

  • Original language description

    Copper amine oxidases (Cu-AO, amine:O2 oxidoreductase) is the key enzyme in the catabolism of biogenic amines. Cu-AO are inhibited by a variety of diverse natural or synthetic substances but any endogenous inhibitor of Cu-AO regulating its activity in vivo has been unambiguously characterized. In our previous studies, we confirmed Cu-AO from etiolated seedling of white bean (Phaseolus vulgaris) to be inhibited by a naturally occurring low-molecular endogenous inhibitor. To enable a detailed chemical andenzymological characterization of the inhibitor, we designed a bioassay-directed fractionation scheme of the seedling extract on the preparative scale. The purified substance was characterized as a reversible non-competitive inhibitor of Cu-AO from Phaseolus vulgaris, Pisum sativum and Lathyrus sativus.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2000

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Chemické listy

  • ISSN

    0009-2770

  • e-ISSN

  • Volume of the periodical

    94

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    XX - stateless person

  • Number of pages

    2

  • Pages from-to

  • UT code for WoS article

  • EID of the result in the Scopus database