Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F01%3A00001303" target="_blank" >RIV/61989592:15310/01:00001303 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Original language description

The octanol-water partition coefficients of 18 potential pharmaceuticals derived from 2-quinolone and 2-indolone were measured by means of MEKC. Their values range from 2.2 to 4.7 (expressed in logarithmic form). The critical micelle concentration (CIVIC) of SIDS was determined conductometrically and the partial specific volumes of the micelles in the buffer (25 mM sodium borate, pH 9.5) were calculated from density data. The values were used for determination of the phase ratio and for estimation of the micelle-water (K-mw) and octanol water (K-ow) partition coefficients. Direct calculation of K-ow from the easily measurable capacity factors (le) gives results comparable with those laboriously determined from K-mw. Extrapolation of the micellar time from the set of migration times of alkylbenzene standards proved to be viable alternative to measurements using a marker.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Separation Science

ISSN

1615-9314

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

9

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

723-728

UT code for WoS article

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EID of the result in the Scopus database

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