Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002220" target="_blank" >RIV/61989592:15310/04:00002220 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane
Original language description
1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) are toxic and mutagenic halogenated compounds. As many other synthetic halogenated aliphatic compounds, both are rather resistant to biodegradation and persist in the environment1. Nevertheless, several bacterial cultures that are able to use DCE as the only carbon and halogen source have been isolated. The most efficient catalysis has been observed with the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10 and substantially low activity with haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT262. A crystallographic analysis of LinB-DCE complex showed non-productive binding of DCE to the enzyme active site, while molecular docking suggested that DCE molecule can possibly bind to the active site but is prevented by chloride ion and/or water molecules3. The different reactivity of DCE and DBE was examined by quantum mechanical calculations as well as by molecular dynamics simulations of enzyme-substrate compl
Czech name
Enzymatická a neenzymatická dehalogenace 1,2-chloroethanu a 1,2-dibromoethanu
Czech description
Byla studována enzymatická a neenzymatická dehalogenace 1,2-chloroethanu a 1,2-dibromoethanu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
ISSN
0232-0061
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
Suppl.
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
275
Pages from-to
261-262
UT code for WoS article
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EID of the result in the Scopus database
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